The Adreno-Genital Syndrome

The adreno-genital syndrome.

DEVELOPMENT OF THE ADRENO-GENITAL SYSTEM Female sex determination, ovarian and adrenal gland ontogeny regulated by Wnt-4 in mice

Although the genetic sex of an embryo is determined at conception by the presence or absence of the Y chromosome, both females and males have bipotential, undifferentiated gonads early in their development. Genes and testicular hormones direct differentiation into either testes or ovaries. The first relevant gene to be identified was the Y-linked master regulatory gene, SRY, since when several ...

Anaesthesia in Adreno-cortical Hypereunction

PATIENTS WITH adreno-cortmal hyperfunctaon-are not frequently presented to anaesthetists. The proper anaesthetac management for adrenalectomy m these cases reqmres a basic understanchng of the physlopathology of the synch'omes caused by hyperfunetlon of the adrenal cortex. The adrenal cortex secretes three types of sterold hormones, file glucocorticolds, and the mmeralo-corticolds and hormones ...

Genital self-amputation and the Klingsor syndrome.

Two psychotic individuals, who performed acts of genital self-amputation, are presented. One of the patients had self-mutilated with the intention of suicide and had also in the past amputated his hand. Psychotic patients with delusions (often religious), sexual conflict associated with guilt, past suicide attempts or other self-destructive behaviour and depression, severe childhood deprivation...

[Adrenogenital syndrome: feminizing genital reconstruction].

Adrenogenital syndrome, or so called congenital adrenal hyperplasia, is caused by a congenital insufficiency of the enzyme 21-hydroxylase, which is responsible for converting cortisol into cholesterol. Because of virilizing effect of androgens overproduction girls develop clitoral hypertrophy and persistent urogenital sinus (common channel for urethra and vagina). Surgical treatment is recommen...